VIO405 - 406. Conditionally Permitted Therapeutic Medications

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VIO405. CONDITIONALLY PERMITTED THERAPEUTIC MEDICATIONS. Only those 13 drugs or medications listed below may be administered within 24 hours of showing:

  • VIO405.1 Phenylbutazone (an NSAID) - The maximum permitted plasma concentration of phenylbutazone is 15.0 micrograms per milliliter.
    • Guidelines: When phenylbutazone is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 2.0 milligrams per pound of body weight should be administered, preferably less. For a 1,000 pound animal, the maximum daily dose is 2.0 grams, which equals two 1.0 gram tablets, or two 1.0 gram units of paste, or 10.0 cc of the injectable (200 milligrams per milliliter). Neither a total daily dose nor part of an injectable dose should be administered during the 12 hours prior to competing. In the event the phenylbutazone is administered orally, half of the maximum daily dose (1.0 gram per 1,000 lbs) can be administered each 12 hours (i.e., 12 hours apart) during a five day treatment program even if such oral administration occurs within 12 hours of competition. Phenylbutazone should not be used for more than five successive days.
  • VIO405.2 Diclofenac (Surpass) (an NSAID) - The maximum permitted plasma concentration of Diclofenac (Surpass) is 0.005 microgram per milliliter.
    • Guidelines: Every 12 hours, not more than 73 mg of diclofenac liposomal cream should be administered (not more than 146 mg per 24 hour period) to one affected site. This 73 mg dose equals a 5-inch ribbon of cream not greater than 1/2 inch in width, which should be rubbed thoroughly into the hair over the joint or affected site using gloved hands. Administration of diclofenac cream should be discontinued 12 hours prior to competing. Do not apply diclofenac cream in combination with any other topical preparations including DMSO, nitrofurazone or liniments, and do not use on an open wound. Diclofenac cream should not be administered for more than 10 successive days.
  • VIO405.3 Flunixin (an NSAID) - The maximum permitted plasma concentration of Flunixin is 1.0 microgram per milliliter.
    • Guidelines: When Flunixin Meglumine (Banamine®) is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 0.5 milligram per pound of body weight should be administered. For a 1,000 pound animal, the maximum daily dose is 500 milligrams, which equals two 250 milligram packets of granules, or one 500 milligram packet of granules, or 500 milligrams of the oral paste (available in 1,500 milligram dose syringes), or 10.0 cc of the injectable (50 milligrams per milliliter). No part of a dose should be administered during the twelve (12) hours prior to competing. Any medicated feed must be consumed and/or removed at least twelve (12) hours prior to competing. The medication should not be used for more than five successive days.
  • VIO405.4 Ketoprofen (an NSAID) - The maximum permitted plasma concentration of Ketoprofen is 40.0 nanograms per milliliter.
    • Guidelines: When Ketoprofen (Ketofen®) is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 1.0 milligram per pound of body weight should be administered. For a 1,000 pound animal, the maximum daily dose is 1.0 gram, which equals 10.0 cc of the injectable (100 milligrams per milliliter). No part of a dose should be administered during the twelve (12) hours prior to competing. The medication should not be used for more than five successive days.
  • VIO405.5 Meclofenamic Acid (an NSAID) - The maximum permitted plasma concentration of Meclofenamic Acid (Arquel®) is 2.5 micrograms per milliliter.
    • Guidelines: When Meclofenamic Acid is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 12 hours, not more than 0.5 milligram per pound of body weight should be administered, preferably less. For a 1,000 pound animal, the maximum 12 hour dose is 0.5 gram, which equals one 500 milligram packet of granules. The medication should not be used for more than five successive days.
  • VIO405.6 Naproxen (an NSAID) - The maximum permitted plasma concentration of Naproxen is 40.0 micrograms per milliliter.
    • Guidelines: When Naproxen is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 4.0 milligrams per pound of body weight should be administered. For a 1,000 pound animal, the maximum daily dose is 4.0 grams, which equals eight 500 milligram tablets. No part of a dose should be administered during the twelve (12) hours prior to competing. Any medicated feed should be consumed and/or removed at least twelve (12) hours prior to competing. The medication should not be used for more than five successive days.
  • VIO405.7 Firocoxib (Equioxx) (an NSAID) - The maximum permitted plasma concentration of Firocoxib (Equioxx) is 0.240 microgram per milliliter.
    • Guidelines: When Firocoxib (Equioxx) is administered, the dose should be accurately calculated according to the actual weight of the animal. For a 1,000 pound animal, the maximum daily does is 45.5 milligrams, which equals 0.1 milligram per kilogram of body weight once daily. No part of a dose should be administered during the 12 hours prior to competition. Firocoxib (Equioxx) should not be administered for more than 14 successive days.
  • VIO405.8 Eltenac (an NSAID) - (PENDING FDA APPROVAL – SEE BELOW) The maximum permitted plasma concentration of Eltenac is 0.1 microgram per milliliter.
    • Guidelines: When Eltenac is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 0.25 milligram per pound of body weight should be administered, preferably less. For a 1,000 pound animal, the maximum daily dose is 250 milligrams, which equals 5.0 cc of the injectable (50 milligrams per milliliter). No part of a dose should be administered during the 12 hours prior to competing. Eltenac should not be administered for more than five successive days. Eltenac has been approved for use pending FDA approval. This medication may not be used until AQHA notified members and exhibitors of the FDA approval. Please watch for statements in AQHA publications and on AQHA’s web site at aqha.com under the Showing section.
  • VIO405.9 Acetazolamide – This medication may only be administered to horses documented through DNA testing to be positive (N/H or H/H) for HYPP (Hyperkalemic Periodic Paralysis). While these rules do not contain a maximum allowable plasma concentration level for Acetazolamide, laboratory detection of levels of Acetazolamide that are not consistent with administration in accordance with the following guidelines may result in prosecution of a rule violation.
    • Guidelines: When Acetazolamide is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 3 milligrams per pound of body weight should be administered. For a 1,000 pound animal, the maximum daily dose is 3 grams.
  • VIO405.10 Furosemide or Lasix® - When used must be administered intravenously at least four hours prior to competition.
  • VIO405.11 Isoxsuprine - Guidelines: When administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 1.6 milligrams per pound of body weight should be administered (usually divided in two equal doses given 12 hours apart). For a 1,000 pound animal, the maximum daily dose is 1,600 milligrams, which equals 80 20-milligram tablets. No part of a dose should be administered during the four hours prior to competing. Any medicated feed should be consumed and/or removed at least four hours prior to competing.
  • VIO405.12 Lidocaine/Mepivicaine - This medication may only be used under actual observation of event management (or designated representative) and/or the official show veterinarian, either of which must sign the medication report form, to aid in the surgical repair of minor skin lacerations which, by their very nature, would not prevent the horse from competing following surgery. Medication report form must be filed with show management as required in VIO103 above.
  • VIO405.13 Dexamethasone - The maximum permitted plasma concentration is 3.0 nanograms per milliliter at the time of competition.
    • Guidelines: In order to help trainers, owners and their veterinarians achieve compliance with this rule in connection with the therapeutic use of dexamethasone, it should be administered in accordance with the guidelines below. These guidelines include several alternative scenarios for dose time and route of administration. Whenever dexamethasone is administered, the dose should be accurately calculated according to the actual weight of the animal. Alternative Number 1. (2.0 mg or less per 100 pounds IV or IM at 12 or more hours before competition). Each 24 hours, not more than 2.0 milligrams of dexamethasone injectable solution per 100 pounds of body weight should be administered intravenously or intramuscularly, preferably less. For a 1,000 pound animal, the maximum daily intravenous or intramuscular dose of dexamethasone injectable solution is 20.0 milligrams, which equals 5.0 milliliters of the injectable solution (4.0 milligrams per milliliter). No part of this dose should be administered during the 12 hours prior to competing. Dexamethasone should not be administered for more than five successive days. Alternative Number 2. (0.5 mg or less per 100 pounds IV at 6 or more hours before competition). Each 24 hours, not more than 0.5 milligram of dexamethasone injectable solution per 100 pounds of body weight should be administered intravenously, preferably less. For a 1,000 pound animal, the maximum daily intravenous dose of dexamethasone injectable solution is 5.0 milligrams, which equals 1.25 milliliters of the injectable solution (4.0 milligrams per milliliter). No part of this dose should be administered during the six hours prior to competing. Dexamethasone should not be administered for more than five successive days. Alternative Number 3. (1.0 mg or less per 100 pounds orally at 6 or more hours before competition). Each 24 hours, not more than 1.0 milligram of dexamethasone powder per 100 pounds of body weight should be administered orally, preferably less. For a 1,000 pound animal, the maximum daily oral dose of dexamethasone powder is 10.0 milligrams, which equals one packet of dexamethasone powder (10.0 milligrams per packet). No part of this dose should be administered during the 6 hours prior to competing. Any medicated feed should be either consumed or removed at least six (6) hours prior to competing. Dexamethasone should not be administered for more than five successive days.
  • VIO406. Administration of these conditionally permitted therapeutic medications does not require that the horse be withdrawn and kept out of competition for a period not less than 24 hours after the medication is administered, nor is there a requirement that a medication report be filed with show management, except when Lidocaine/Mepivicaine is used per VIO405.12 above.